Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine.

doi:10.1128/JVI.66.12.7128-7135.1992

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Article

Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine.

Journal of virology - 1 Dec 1992

Gu Z, Gao Q, Li X, Parniak M A, Wainberg M A

Abstract excerpt

We have used the technique of in vitro selection to generate variants of human immunodeficiency virus type 1 (HIV-1) that are resistant to 2',3'-dideoxyinosine (ddI) and cross-resistant to 2',3'-dideoxycytidine (ddC). The complete reverse transcriptase (RT)-coding regions, plus portions of flanking sequences, of viruses possessing a ddI-resistant phenotype were cloned and sequenced by polymerase chain reaction...

Topics

Acquired Immunodeficiency Syndrome
Base Sequence
Cell Line
Cloning, Molecular
Didanosine
Drug Resistance, Microbial
Genetic Variation
HIV Reverse Transcriptase
HIV-1
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Restriction Mapping

Zalcitabine

Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 1279198
DOI: 10.1128/JVI.66.12.7128-7135.1992
PMCID: PMC240397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1279198-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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