Chromosome 10 allelic loss in malignant melanoma.

doi:10.1002/gcc.2870080307

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Article

Chromosome 10 allelic loss in malignant melanoma.

Genes, chromosomes & cancer - 1 Nov 1993

Isshiki K, Elder D E, Guerry D, Linnenbach A J

Abstract excerpt

The involvement of tumor suppressor genes in the progression of melanoma has been suggested by the frequent deletion of specific regions of the genome in melanoma. In this study, a panel of 18 surgically removed melanomas from 15 patients was analyzed for loss of heterozygosity (LOH) at 10 polymo...

Topics

Alleles
Blotting, Southern
Chromosome Deletion
Chromosomes, Human, Pair 10
DNA, Neoplasm
DNA, Satellite
Genetic Linkage
Heterozygote
Humans
Melanoma
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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