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Article

Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas.

Virchows Archiv : an international journal of pathology - 1 May 2000

Reifenberger J, Wolter M, Boström J, Büschges R, Schulte K W, Megahed M, Ruzicka T, Reifenberger G

Abstract excerpt

Malignant melanomas frequently show loss of alleles on the long arm of chromosome 10. The PTEN (MMAC1) gene has been identified as a tumour suppressor gene at 10q23.3 that is mutated in various types of advanced human cancers. We have investigated a series of 40 sporadic melanomas from 37 patients (15 primary cutaneous melanomas and 25 melanoma metastases) for allelic losses on chromosome 10, as well as for...

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Share to Chromosomes, Human, Pair 10
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

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Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to RNA, Neoplasm

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Source

Identifiers

PMID: 10881743
DOI: 10.1007/s004280050477

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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