Article
PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines
1 Dec 2002
Abstract excerpt
Deletions detected in cytogenetic and loss of heterozygosity (LOH) studies indicate that at least one tumour suppressor gene maps to the long arm of chromosome 10. Previous deletion mapping studies have observed LOH on 10q in about 30% of melanomas analysed. The PTEN gene, mapping to chromosome band 10q23.3, encodes a protein with both lipid and protein phosphatase activity. Somatic mutations and deletions in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.