Article
Functional evidence of novel tumor suppressor genes for cutaneous malignant melanoma.
Cancer research - 1 Feb 1999
Parris C N, Harris J D, Griffin D K, Cuthbert A P, Silver A J, Newbold R F
Abstract excerpt
Losses of heterozygosity involving chromosomes 9 and 10 are frequent events in the development and progression of cutaneous malignant melanoma. To investigate whether specifically deleted chromosomal regions encode tumor suppressor genes (TSGs), we introduced normal chromosome 10 into the tumorigenic human metastatic melanoma cell line UACC-903 by microcell fusion. In addition, two chromosome 9 derivatives that...
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