Article
Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer.
Genes, chromosomes & cancer - 1 Dec 1996
Komiya A, Suzuki H, Ueda T, Yatani R, Emi M, Ito H, Shimazaki J
Abstract excerpt
DNA samples from tumors and paired normal tissues from 48 patients with prostate cancer (stage B, 16 cases; stage C, 14 cases; stage D, 18 cases) were examined with 26 polymorphic markers spanning chromosome 10. Allelic losses were observed in 17 of the 46 cases (37%) that were informative with at least one of the markers. Detailed deletion mapping identified two distict commonly deleted regions on the long arm...
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