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Article

Biomarkers of aging: correlation of DNA I-compound levels with median lifespan of calorically restricted and ad libitum fed rats and mice.

Mutation research - 1 Dec 1993

Randerath K, Zhou G D, Hart R W, Turturro A, Randerath E

Abstract excerpt

I-compounds are species-, tissue-, genotype-, gender-, and diet-dependent bulky DNA modifications whose levels increase with animal age. While a few of these DNA modifications represent oxidation products, the majority of I-compounds appear to be derived from as yet unidentified endogenous DNA-re...

Topics

Aging
Animals
DNA
Energy Intake
Genotype
Kidney
Life Expectancy
Liver
Mice
Mice, Inbred Strains
Nucleotides
Rats
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7507561
DOI: 10.1016/0921-8734(93)90024-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7507561-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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