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Article

Metabolic profiling of accelerated aging ERCC1 d/- mice.

Journal of proteome research - 2 Jul 2010

Nevedomskaya Ekaterina, Meissner Axel, Goraler Sibel, de Waard Monique, Ridwan Yanto, Zondag Gerben, van der Pluijm Ingrid, Deelder André M, Mayboroda Oleg A

Abstract excerpt

Aging is a fundamental biological process for which the mechanism is still largely unknown due to its complex and multifactorial nature. Animal models allow us to simplify this complexity and to study individual factors separately. As there are many causative links between DNA repair deficiency and aging, we studied the ERCC1(d/-) mouse, which has a modified ERCC1 gene, involved in the Nucleotide Excision Repair,...

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Source

Identifiers

PMID: 20507129
DOI: 10.1021/pr100210k

Genes

ERCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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