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Article

Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline.

DNA repair - 1 Mar 2003

Cabelof Diane C, Yanamadala Sunitha, Raffoul Julian J, Guo ZhongMao, Soofi Abdulsalam, Heydari Ahmad R

Abstract excerpt

Caloric restriction is a potent experimental manipulation that extends mean and maximum life span and delays the onset and progression of tumors in laboratory rodents. While caloric restriction (CR) clearly protects the genome from deleterious damage, the mechanism by which genomic stability is achieved remains unclear. We provide evidence that CR promotes genomic stability by increasing DNA repair capacity,...

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PMID: 12547392
DOI: 10.1016/s1568-7864(02)00219-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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