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Article

Effects of genotype and diet on age-related lesions in ad libitum fed and calorie-restricted F344, BN, and BNF3F1 rats.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 1999

Lipman R D, Dallal G E, Bronson R T

Abstract excerpt

The effects of calorie restriction (CR) on age-related lesions in Brown Norway, Fischer 344, and BNF3F1 hybrid rats are presented. A logistic regression analysis of data from histologic samples from rats of each genotype, sex, and diet at 12, 18, 24, 30, and 36 months of age demonstrated the effects of age, diet, and sex on lesion prevalence in all three genotypes. CR reduced the prevalence of neoplastic,...

Topics

Adrenal Glands
Aging
Animals
Energy Intake
Female
Genotype
Kidney
Liver
Male
Myocardium
Pancreas
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred BN

Rats, Inbred F344

Sex Factors

Testis

Thyroid Gland

Source

Identifiers

PMID: 10619311
DOI: 10.1093/gerona/54.11.b478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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