Article
Background lesions during a 24-month observation period in connexin 32-deficient mice.
The Journal of veterinary medical science - 1 Feb 2013
Igarashi Isao, Makino Toshihiko, Suzuki Yoko, Kai Kiyonori, Teranishi Munehiro, Takasaki Wataru, Furuhama Kazuhisa
Abstract excerpt
Connexin 32 (Cx32) is a major gap junction protein in the liver. Neoplastic and non-neoplastic lesions were examined in Cx32-deficient (Cx32KO) mice maintained for 24-month, and compared with those in wild-type mice as a corresponding control. In neoplastic lesions, hepatocellular carcinoma increased significantly only in male Cx32KO mice, suggesting that Cx32 deficiency may be related to their pathogenesis. For...
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