Transforming growth factor-alpha in carcinogen-induced F344 rat hepatic foci.

doi:10.1006/taap.1996.0206

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Article

Transforming growth factor-alpha in carcinogen-induced F344 rat hepatic foci.

Toxicology and applied pharmacology - 1 Sept 1996

Steinmetz K L, Klaunig J E

Abstract excerpt

Transforming growth factor-alpha (TGF alpha) is a positive growth regulator in epithelial cells, including hepatocytes. Overexpression of TGF alpha has been associated with increased growth and malignancy of end-stage cancers in humans and rodents. The overall aim of this study was to characteriz...

Topics

Adenoma
Animals
Carcinoma
Coloring Agents
DNA
Diethylnitrosamine
Glutathione Transferase
Immunohistochemistry
Liver
Liver Neoplasms, Experimental
Male
Phenotype
Rats
Rats, Inbred F344
Time Factors
Transforming Growth Factor alpha

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