Article
WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice.
Carcinogenesis - 1 Sept 2003
Moennikes Oliver, Stahl Sabine, Bannasch Peter, Buchmann Albrecht, Schwarz Michael
Abstract excerpt
Connexin32 (Cx32) is the major gap junction forming protein in liver and lack of functional Cx32 enhances hepatocarcinogenesis. Many tumour-promoting agents block gap junctional intercellular communication, which may favour clonal expansion of neoplastic cells. We recently demonstrated that liver tumourigenesis is accelerated in Cx32-wild-type but not in Cx32-null mice by the model tumour promoter phenobarbital...
Topics
- Animals
- Carcinogens
- Cocarcinogenesis
- Connexins
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C3H
- Mice, Mutant Strains
- Mutation
- Pyrimidines