Article
Resistance to neutralization by broadly reactive antibodies to the human immunodeficiency virus type 1 gp120 glycoprotein conferred by a gp41 amino acid change.
Journal of virology - 1 Feb 1994
Thali M, Charles M, Furman C, Cavacini L, Posner M, Robinson J, Sodroski J
Abstract excerpt
A neutralization-resistant variant of human immunodeficiency virus type 1 (HIV-1) that emerged during in vitro propagation of the virus in the presence of neutralizing serum from an infected individual has been described. A threonine-for-alanine substitution at position 582 in the gp41 transmembr...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Binding, Competitive
- CD4 Antigens
- Cells, Cultured
- Epitopes
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1
- Mutation
- Neutralization Tests