Article
Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites.
Journal of virology - 1 Dec 1996
Watkins B A, Buge S, Aldrich K, Davis A E, Robinson J, Reitz M S, Robert-Guroff M
Abstract excerpt
The ability of human immunodeficiency virus type 1 (HIV-1) to replicate in the presence of strong immune responses to the virus may be due to its high mutation rate, which provides envelope gene variability for selection of neutralization-resistant variants. Understanding neutralization escape me...
Topics
- Animals
- Binding Sites, Antibody
- CD4 Antigens
- COS Cells
- Epitopes
- Genetic Variation
- HIV Antibodies
- HIV Antigens
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV Infections
- HIV-1
- Humans
- Neutralization Tests
- Point Mutation