Article
Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41.
PLoS medicine - 3 Jan 2008
Blish Catherine A, Nguyen Minh-An, Overbaugh Julie
Abstract excerpt
BACKGROUND: The generation of broadly neutralizing antibodies is a priority in the design of vaccines against HIV-1. Unfortunately, most antibodies to HIV-1 are narrow in their specificity, and a basic understanding of how to develop antibodies with broad neutralizing activity is needed. Designing methods to target antibodies to conserved HIV-1 epitopes may allow for the generation of broadly neutralizing...
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