Mutations in both gp120 and gp41 are responsible for the broad neutralization resistance of variant human immunodeficiency virus type 1 MN to antibodies directed at V3 and non-V3 epitopes.

doi:10.1128/JVI.72.9.7099-7107.1998

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Article

Mutations in both gp120 and gp41 are responsible for the broad neutralization resistance of variant human immunodeficiency virus type 1 MN to antibodies directed at V3 and non-V3 epitopes.

Journal of virology - 1 Sept 1998

Park E J, Vujcic L K, Anand R, Theodore T S, Quinnan G V

Abstract excerpt

The escape of human immunodeficiency virus type 1 from effects of neutralizing antibodies was studied by using neutralization-resistant (NR) variants generated by growing the neutralization-sensitive (NS) wild-type MN virus in the presence of human serum with neutralizing antibodies, more than 99...

Topics

Amino Acid Sequence
Base Sequence
Cell Line, Transformed
Cloning, Molecular
DNA, Viral
Epitopes, B-Lymphocyte
Gene Products, env
Genetic Variation
HIV Antibodies
HIV Envelope Protein gp120
HIV Envelope Protein gp41

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV-1

Humans

Immunophenotyping

Molecular Sequence Data

Mutation

Neutralization Tests

Peptide Fragments

Source

Open in PubMed Open full text

Identifiers

PMID: 9696803
DOI: 10.1128/JVI.72.9.7099-7107.1998
PMCID: PMC109931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9696803-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutations in both gp120 and gp41 are responsible for the broad neutralization resistance of variant human immunodeficiency virus type 1 MN to antibodies directed at V3 and non-V3 epitopes.PMID 9696803Read ↗

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