Article
Immune escape by human immunodeficiency virus type 1 from neutralizing antibodies: evidence for multiple pathways.
Journal of virology - 1 Dec 1993
Watkins B A, Reitz M S, Wilson C A, Aldrich K, Davis A E, Robert-Guroff M
Abstract excerpt
Sera from many HIV-1-infected individuals contain broadly reactive, specific neutralizing antibodies. Despite their broad reactivity, variant viruses, resistant to neutralization, can be selected in vitro in the presence of such antisera. We have previously shown that neutralization resistance of...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Viral
- CD4 Antigens
- Cells, Cultured
- Epitopes
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Protein Conformation
- Selection, Genetic