Article
Immune escape by human immunodeficiency virus type 1 from neutralizing antibodies: evidence for multiple pathways.
Journal of virology - 1 Dec 1993
Watkins B A, Reitz M S, Wilson C A, Aldrich K, Davis A E, Robert-Guroff M
Abstract excerpt
Sera from many HIV-1-infected individuals contain broadly reactive, specific neutralizing antibodies. Despite their broad reactivity, variant viruses, resistant to neutralization, can be selected in vitro in the presence of such antisera. We have previously shown that neutralization resistance of an escape mutant with an amino acid substitution in the transmembrane protein (A582T) occurs because of alteration of...
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