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Article

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding.

Journal of virology - 1 Dec 1990

Olshevsky U, Helseth E, Furman C, Li J, Haseltine W, Sodroski J

Abstract excerpt

The binding of the CD4 receptor by the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein is important for virus entry and cytopathic effect. To investigate the CD4-binding region of the gp120 glycoprotein, we altered gp120 amino acids, excluding cysteines, that are conserved among the primate immunodeficiency viruses utilizing the CD4 receptor. Changes in two hydrophobic regions (Thr-257 in...

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Identifiers

PMID: 2243375
DOI: 10.1128/JVI.64.12.5701-5707.1990
PMCID: PMC248709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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