Article
Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding.
Journal of virology - 1 Dec 1990
Olshevsky U, Helseth E, Furman C, Li J, Haseltine W, Sodroski J
Abstract excerpt
The binding of the CD4 receptor by the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein is important for virus entry and cytopathic effect. To investigate the CD4-binding region of the gp120 glycoprotein, we altered gp120 amino acids, excluding cysteines, that are conserve...
Topics
- Amino Acid Sequence
- Animals
- CD4 Antigens
- Cell Line
- HIV Envelope Protein gp120
- HIV-1
- HIV-2
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation
- Restriction Mapping
- Sequence Homology, Nucleic Acid
- Simian Immunodeficiency Virus
- Transfection