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Article

Sequences in glycoprotein gp41, the CD4 binding site, and the V2 domain regulate sensitivity and resistance of HIV-1 to broadly neutralizing antibodies.

Journal of virology - 1 Nov 2012

O'Rourke Sara M, Schweighardt Becky, Phung Pham, Mesa Kathryn A, Vollrath Aaron L, Tatsuno Gwen P, To Briana, Sinangil Faruk, Limoli Kay, Wrin Terri, Berman Phillip W

Abstract excerpt

The swarm of quasispecies that evolves in each HIV-1-infected individual represents a source of closely related Env protein variants that can be used to explore various aspects of HIV-1 biology. In this study, we made use of these variants to identify mutations that confer sensitivity and resista...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22933284
DOI: 10.1128/JVI.01352-12
PMCID: PMC3486483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22933284-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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