Article
The site of an immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 does not constitute the neutralization epitope.
Journal of virology - 1 Jul 1990
Wilson C, Reitz M S, Aldrich K, Klasse P J, Blomberg J, Gallo R C, Robert-Guroff M
Abstract excerpt
We previously reported the in vitro generation of a neutralization-resistant variant of the molecularly cloned isolate of human immunodeficiency virus type 1 (HIV-1), HXB2D. The molecular basis for the resistance was shown to be a point mutation in the env gene, causing the substitution of threonine for alanine at position 582 of gp41. Here, we show the variant to be resistant to syncytium inhibition as well as...
Topics
- Amino Acid Sequence
- Antigens, Viral
- Base Sequence
- Cloning, Molecular
- DNA Mutational Analysis
- HIV Antibodies
- HIV Envelope Protein gp41
- HIV-1
- Humans
- In Vitro Techniques