Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects.

doi:10.1093/infdis/165.1.105

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Article

Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects.

The Journal of infectious diseases - 1 Jan 1992

Boucher C A, O'Sullivan E, Mulder J W, Ramautarsing C, Kellam P, Darby G, Lange J M, Goudsmit J, Larder B A

Abstract excerpt

The order of appearance in the reverse transcriptase gene of four mutations implicated in the development of resistance to zidovudine was investigated by selective polymerase chain reaction. Serial human immunodeficiency virus isolates were studied from 18 initially asymptomatic individuals who had been treated with zidovudine for 2 years. Most subjects had similar patterns. The first mutation occurred...

Topics

Acquired Immunodeficiency Syndrome
Codon
Cohort Studies
Drug Resistance, Microbial
Genotype
HIV
HIV Infections
HeLa Cells
Homosexuality
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Time Factors

Viral Plaque Assay

Zidovudine

Source

Open in PubMed

Identifiers

PMID: 1370174
DOI: 10.1093/infdis/165.1.105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370174-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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