Article
High-level resistance to zidovudine but not to zalcitabine or didanosine in human immunodeficiency virus from children receiving antiretroviral therapy.
The Journal of pediatrics - 1 Jul 1993
Husson R N, Shirasaka T, Butler K M, Pizzo P A, Mitsuya H
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) isolates from children receiving long-term therapy with an alternating regimen of zidovudine and zalcitabine, or with didanosine monotherapy, were evaluated for resistance to zidovudine, zalcitabine, and didanosine, and for mutations known to be associa...
Topics
- Acquired Immunodeficiency Syndrome
- Child
- Child, Preschool
- DNA, Viral
- Didanosine
- Drug Resistance, Microbial
- Drug Therapy, Combination
- HIV-1
- Humans
- Infant
- Microbial Sensitivity Tests
- Mutation
- Polymerase Chain Reaction
- Time Factors
- Zalcitabine
- Zidovudine