Article
Persistence of lamivudine-sensitive HIV-1 quasispecies in the presence of lamivudine in vitro and in vivo.
Journal of acquired immune deficiency syndromes (1999) - 1 Apr 2007
Allers Kristina, Knoepfel Stefanie A, Rauch Pia, Walter Hauke, Opravil Milos, Fischer Marek, Günthard Huldrych F, Metzner Karin J
Abstract excerpt
The establishment of persistent infection is one of the major obstacles facing the eradication of HIV-1. To improve our understanding of the mechanisms of viral persistence, we investigated the fate of defined viral quasispecies under conditions that might favor their eradication. We retrospectively analyzed changes in viral populations in HIV-1-infected patients treated with zidovudine/lamivudine and...
Topics
- Anti-HIV Agents
- Drug Resistance, Viral
- Drug Therapy, Combination
- HIV Infections
- HIV-1
- Humans
- Kinetics
- Lamivudine
- Mutation
- RNA, Viral
- Retrospective Studies
- T-Lymphocytes
- Time Factors
- Viral Load