Emergence of dual resistance to zidovudine and lamivudine in HIV-1-infected patients treated with zidovudine plus lamivudine as initial therapy.

doi:10.1097/00126334-200001010-00004

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Article

Emergence of dual resistance to zidovudine and lamivudine in HIV-1-infected patients treated with zidovudine plus lamivudine as initial therapy.

Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2000

Kuritzkes D R, Shugarts D, Bakhtiari M, Poticha D, Johnson J, Rubin M, Gingeras T R, Kennedy M, Eron J J

Abstract excerpt

Presence of mutations associated with resistance to zidovudine or lamivudine was determined in isolates of HIV-1 obtained after long-term follow-up of 64 infected individuals who received zidovudine, lamivudine, or both drugs as initial antiretroviral therapy. Zidovudine resistance mutations were less frequent in isolates from patients treated with combination lamivudine plus zidovudine compared with zidovudine...

Topics

Amino Acid Sequence
Anti-HIV Agents
Codon
Drug Resistance, Microbial
Drug Therapy, Combination
HIV Infections
HIV Reverse Transcriptase
HIV-1
Humans
Lamivudine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Randomized Controlled Trials as Topic

Reverse Transcriptase Inhibitors

Sequence Homology, Amino Acid

Zidovudine

Source

Open in PubMed

Identifiers

PMID: 10708053
DOI: 10.1097/00126334-200001010-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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