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Article

Persistence of azidothymidine-resistant human immunodeficiency virus type 1 RNA genotypes in posttreatment sera.

Journal of virology - 1 Sept 1992

Albert J, Wahlberg J, Lundeberg J, Cox S, Sandström E, Wahren B, Uhlén M

Abstract excerpt

The rate of reversion from azidothymidine (zidovudine; AZT) resistance was studied by direct sequencing of human immunodeficiency virus type 1 (HIV-1) virion RNA in sera from four patients who discontinued long-term treatment. Before cessation of treatment, all four patients harbored HIV-1 with multiple mutations reported to confer AZT resistance. In three patients, slow reversions of these mutations starting...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Drug Resistance, Microbial
Genetic Variation
Genotype
HIV Reverse Transcriptase
HIV-1
Humans
Leukocytes, Mononuclear
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

RNA-Directed DNA Polymerase

Sequence Homology, Nucleic Acid

Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 1380098
DOI: 10.1128/JVI.66.9.5627-5630.1992
PMCID: PMC289127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1380098-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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