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Article

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma.

Nature - 11 Jan 2001

Soengas M S, Capodieci P, Polsky D, Mora J, Esteller M, Opitz-Araya X, McCombie R, Herman J G, Gerald W L, Lazebnik Y A, Cordón-Cardó C, Lowe S W

Abstract excerpt

Metastatic melanoma is a deadly cancer that fails to respond to conventional chemotherapy and is poorly understood at the molecular level. p53 mutations often occur in aggressive and chemoresistant cancers but are rarely observed in melanoma. Here we show that metastatic melanomas often lose Apaf...

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Identifiers

PMID: 11196646
DOI: 10.1038/35051606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11196646-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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