Article
Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma.
Oncogene - 20 Jul 1995
Liu L, Lassam N J, Slingerland J M, Bailey D, Cole D, Jenkins R, Hogg D
Abstract excerpt
The gene encoding the cell cycle inhibitor p16INK4A (also known as p16, MTS1, CDKN2 and INK4) has been mapped to human chromosome band 9p21, a region that also contains a putative melanoma susceptibility gene. Although germline mutations in the coding region of the p16INK4A gene have been detected in some families with inherited melanoma, many other families show no evidence of such mutations and hence the role...
Topics
- Alleles
- Animals
- Base Sequence
- Brain Neoplasms
- Carrier Proteins
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- DNA
- Embryo, Mammalian
- Enzyme Inhibitors