Article
Frequent p16-independent inactivation of p14ARF in human melanoma.
Journal of the National Cancer Institute - 4 Jun 2008
Freedberg Daniel E, Rigas Sushila H, Russak Julie, Gai Weiming, Kaplow Margarita, Osman Iman, Turner Faye, Randerson-Moor Juliette A, Houghton Alan, Busam Klaus, Timothy Bishop D, Bastian Boris C, Newton-Bishop Julia A, Polsky David
Abstract excerpt
BACKGROUND: The tumor suppressors p14(ARF) (ARF) and p16(INK4A) (p16) are encoded by overlapping reading frames at the CDKN2A/INK4A locus on chromosome 9p21. In human melanoma, the accumulated evidence has suggested that the predominant tumor suppressor at 9p21 is p16, not ARF. However, recent observations from melanoma-prone families and murine melanoma models suggest a p16-independent tumor suppressor role for...
Topics
- Animals
- Cell Line, Tumor
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Methylation
- Gene Deletion
- Gene Silencing
- Genes, p16
- Humans
- Immunoblotting