Article
CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds.
The Journal of investigative dermatology - 1 Dec 1998
Fargnoli M C, Chimenti S, Keller G, Soyer H P, Dal Pozzo V, Höfler H, Peris K
Abstract excerpt
Germline mutations in the cyclin-dependent kinase inhibitor 2a (CDKN2a) gene, which maps to the 9p21 chromosomal region and encodes the cyclin-dependent kinase inhibitor p16INK4a, have been detected in a proportion of familial melanoma kindreds, suggesting that it is the putative 9p21-linked melanoma susceptibility gene. The p19ARF transcript, an alternative spliced form of the CDKN2a gene, has recently been...
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