CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds.

doi:10.1046/j.1523-1747.1998.00412.x

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Article

CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds.

The Journal of investigative dermatology - 1 Dec 1998

Fargnoli M C, Chimenti S, Keller G, Soyer H P, Dal Pozzo V, Höfler H, Peris K

Abstract excerpt

Germline mutations in the cyclin-dependent kinase inhibitor 2a (CDKN2a) gene, which maps to the 9p21 chromosomal region and encodes the cyclin-dependent kinase inhibitor p16INK4a, have been detected in a proportion of familial melanoma kindreds, suggesting that it is the putative 9p21-linked mela...

Topics

Adult
Aged
Family Health
Female
Genes, p16
Genetic Variation
Germ-Line Mutation
Humans
Male
Melanoma
Middle Aged
Pedigree
Point Mutation
Proteins
Tumor Suppressor Protein p14ARF

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