Article
Direct interaction with and activation of p53 by SMAR1 retards cell‐cycle progression at G<sub>2</sub>/M phase and delays tumor growth in mice
6 Dec 2002
Abstract excerpt
The tumor-suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor-suppressor activity by either causing cell-cycle arrest (G(1)/S or G(2)/M) or inducing cells to undergo apoptosis. This function of wild-type p53 as "guardian of the genome" is presumably achieved by forming molecular complexes with different DNA targets as well as by interacting with...
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