Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications.

doi:10.1073/pnas.91.25.12163

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Article

Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 1994

Rothenfluh H S, Gibbs A J, Blanden R V, Steele E J

Abstract excerpt

We analyzed the DNA sequence structure of the 5' flanking and coding regions of 52 VH186.2-related germ-line genes isolated by PCR from C57BL/6J and BALB/c mice. The aligned coding regions display hypervariable and conserved regions corresponding to some of the complementarity-determining regions (CDRs) and framework regions (FRs) found in somatically mutated rearranged immunoglobulin variable genes. Most of the...

Topics

Amino Acid Sequence
Animals
Biological Evolution
DNA
Embryo, Mammalian
Female
Genes, Immunoglobulin
Genetic Variation
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Molecular Sequence Data

Phylogeny

Polymerase Chain Reaction

Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 7991601
DOI: 10.1073/pnas.91.25.12163
PMCID: PMC45397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7991601-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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