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Article

Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 1994

Rothenfluh H S, Gibbs A J, Blanden R V, Steele E J

Abstract excerpt

We analyzed the DNA sequence structure of the 5' flanking and coding regions of 52 VH186.2-related germ-line genes isolated by PCR from C57BL/6J and BALB/c mice. The aligned coding regions display hypervariable and conserved regions corresponding to some of the complementarity-determining regions (CDRs) and framework regions (FRs) found in somatically mutated rearranged immunoglobulin variable genes. Most of the...

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Identifiers

PMID: 7991601
DOI: 10.1073/pnas.91.25.12163
PMCID: PMC45397

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