Article
On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood.
Blood - 1 Dec 1995
Endenburg S C, Hantgan R R, Lindeboom-Blokzijl L, Lankhof H, Jerome W G, Lewis J C, Sixma J J, de Groot P G
Abstract excerpt
Platelet adhesion to fibrin at high shear rates depends on both the glycoprotein (GP) IIb:IIIa complex and a secondary interaction between GPIb and von Willebrand factor (vWF). This alternative link between platelets and vWF in promoting platelet adhesion to fibrin has been examined in flowing wh...
Topics
- Bernard-Soulier Syndrome
- Binding Sites
- Blood Flow Velocity
- Blood Platelets
- Fibrin
- Humans
- In Vitro Techniques
- Microscopy, Immunoelectron
- Mutation
- Perfusion
- Platelet Adhesiveness
- Platelet Glycoprotein GPIIb-IIIa Complex
- Thrombasthenia
- von Willebrand Diseases
- von Willebrand Factor