Article
On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood.
Blood - 1 Dec 1995
Endenburg S C, Hantgan R R, Lindeboom-Blokzijl L, Lankhof H, Jerome W G, Lewis J C, Sixma J J, de Groot P G
Abstract excerpt
Platelet adhesion to fibrin at high shear rates depends on both the glycoprotein (GP) IIb:IIIa complex and a secondary interaction between GPIb and von Willebrand factor (vWF). This alternative link between platelets and vWF in promoting platelet adhesion to fibrin has been examined in flowing whole blood with a rectangular perfusion chamber. Optimal adhesion required both platelets and vWF, as shown by the...
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