Article
The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets.
The Journal of biological chemistry - 25 Sept 1991
Nesheim M, Pittman D D, Giles A R, Fass D N, Wang J H, Slonosky D, Kaufman R J
Abstract excerpt
The binding of 35S-labeled recombinant human Factor VIII to activated human platelets was studied in the presence and absence of exogenous plasma von Willebrand factor. In the absence of added von Willebrand Factor, platelets bound 210 molecules of Factor VIII/platelet when the unbound Factor VII...
Topics
- Antibodies, Monoclonal
- Autoradiography
- Blood Platelets
- DNA
- Electrophoresis, Polyacrylamide Gel
- Factor VIII
- Humans
- Mutation
- Platelet Activation
- Recombinant Proteins
- Thrombin
- von Willebrand Factor