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Article

Selectin-like kinetics and biomechanics promote rapid platelet adhesion in flow: the GPIb(alpha)-vWF tether bond.

Biophysical journal - 1 Jul 2002

Doggett Teresa A, Girdhar Gaurav, Lawshé Avril, Schmidtke David W, Laurenzi Ian J, Diamond Scott L, Diacovo Thomas G

Abstract excerpt

The ability of platelets to tether to and translocate on injured vascular endothelium relies on the interaction between the platelet glycoprotein receptor Ib alpha (GPIb(alpha)) and the A1 domain of von Willebrand factor (vWF-A1). To date, limited information exists on the kinetics that govern platelet interactions with vWF in hemodynamic flow. We now report that the GPIb(alpha)-vWF-A1 tether bond displays...

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Source

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Identifiers

PMID: 12080112
DOI: 10.1016/S0006-3495(02)75161-8
PMCID: PMC1302139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Selectin-like kinetics and biomechanics promote rapid platelet adhesion in flow: the GPIb(alpha)-vWF tether bond.PMID 12080112Read ↗

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