Article
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.
Scientific reports - 17 Jul 2020
Brouns Sanne L N, van Geffen Johanna P, Campello Elena, Swieringa Frauke, Spiezia Luca, van Oerle René, Provenzale Isabella, Verdoold Remco, Farndale Richard W, Clemetson Kenneth J, Spronk Henri M H, van der Meijden Paola E J, Cavill Rachel, Kuijpers Marijke J E, Castoldi Elisabetta, Simioni Paolo, Heemskerk Johan W M
Abstract excerpt
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet activation, thrombus structure and fibrin clot formation in real time using flowing whole blood. Microspots were made from distinct platelet-adhesive surfaces in the absence or presence of...
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