Article
Plasma fibronectin promotes thrombus growth and stability in injured arterioles.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Ni Heyu, Yuen Peter S T, Papalia Jessie M, Trevithick Jane E, Sakai Takao, Fässler Reinhard, Hynes Richard O, Wagner Denisa D
Abstract excerpt
Mice lacking both of the best-known platelet ligands, von Willebrand factor and fibrinogen, can still form occlusive thrombi in injured arterioles. The platelets of these animals accumulate excessive amounts of fibronectin (FN). These observations led us to examine the contribution of plasma FN (pFN) to thrombus formation. Inactivation of the FN gene in FN conditional knockout mice reduced pFN levels to <2% and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.