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Article

Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions.

Annals of the New York Academy of Sciences - 1 Jan 2001

Remijn J A, Lounes K C, Hogan K A, Lord S T, Galanakis D K, Sixma J J, De Groot P G

Abstract excerpt

In this paper we report on studies of platelet adhesion to several fibrinogen gamma chain variants under physiological flow conditions. Reduced platelet adhesion was found to patient dysfibrinogen Vlissingen and its recombinant form (deletion of gamma 319-320). Furthermore, substitutions of the amino acids 318, 320, or both in the recombinant fibrinogen gamma chain showed a strong decrease in platelet adhesion...

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Identifiers

PMID: 11460499
DOI: 10.1111/j.1749-6632.2001.tb03528.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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