Article
Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa.
Blood - 1 Aug 2008
Marx Isabelle, Christophe Olivier D, Lenting Peter J, Rupin Alain, Vallez Marie-Odile, Verbeuren Tony J, Denis Cécile V
Abstract excerpt
The role of von Willebrand factor (VWF) in thrombosis involves its binding to a number of ligands. To investigate the relative importance of these particular interactions in the thrombosis process, we have introduced mutations into murine VWF (mVWF) cDNA inhibiting VWF binding to glycoprotein (Gp...
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