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Article

Characterization of Mycoplasma hominis mutations involved in resistance to fluoroquinolones.

Antimicrobial agents and chemotherapy - 1 Feb 1997

Bebear C M, Bové J M, Bebear C, Renaudin J

Abstract excerpt

Fluoroquinolone-resistant mutants of Mycoplasma hominis were selected in vitro from the PG21 susceptible reference strain either by multistep selection on increasing concentrations of various fluoroquinolones or by one-step selection on agar medium with ofloxacin. The quinolone resistance-determining regions (QRDR) of the structural genes encoding the A and b subunits of DNA gyrase were amplified by PCR, and the...

Topics

Amino Acid Sequence
Anti-Infective Agents
Base Sequence
DNA Gyrase
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Fluoroquinolones
Molecular Sequence Data
Mutation
Mycoplasma hominis
Polymerase Chain Reaction

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Identifiers

PMID: 9021178
DOI: 10.1128/AAC.41.2.269
PMCID: PMC163700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9021178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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