Article
Mutations in the gyrA and grlA genes of quinolone-resistant clinical isolates of methicillin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy - 1 Sept 1996
Takahata M, Yonezawa M, Kurose S, Futakuchi N, Matsubara N, Watanabe Y, Narita H
Abstract excerpt
The mutations in the quinolone-resistance determining regions (QRDR) of the gyrA, gyrB and grlA genes and in the norA gene from five clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) were examined by DNA sequencing. The mutation from Ser84 to Leu in GyrA was associated with...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Fluoroquinolones
- Methicillin Resistance
- Microbial Sensitivity Tests
- Multidrug Resistance-Associated Proteins
- Mutation
- Staphylococcus aureus