Article
Extended spectrum of quinolone resistance, even to a potential latter third-generation agent, as a result of a minimum of two GrlA and two GyrA alterations in quinolone-resistant Staphylococcus aureus.
Chemotherapy - 1 Jan 2010
Yoon Eun-Jeong, Lee Chun-Yeong, Shim Mi-Ja, Min Yu-Hong, Kwon Ae-Ran, Lee Jongseo, Choi Eung-Chil
Abstract excerpt
BACKGROUND: This study was performed to determine the extended spectrum of quinolone resistance caused by increased mutations within the target enzymes of quinolones. METHODS: The minimum inhibitory concentrations (MICs) for ciprofloxacin, sparfloxacin, trovafloxacin and DW286 were determined against 98 ciprofloxacin-resistant Staphylococcus aureus strains. Also, PCR-amplified grlA, grlB, gyrA and gyrB DNA...
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