Article
Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immunogenic, and protective in seronegative chimpanzees, even when RSV antibodies are infused shortly before immunization.
Vaccine - 1 Jun 1995
Crowe J E, Bui P T, Siber G R, Elkins W R, Chanock R M, Murphy B R
Abstract excerpt
A cold-passaged (cp) temperature-sensitive (ts) RSV mutant, designated RSV cpts-530, which possesses host-range mutations acquired during 52 passages at low temperature in bovine tissue culture and one or more ts mutations induced by chemical mutagenesis (shut-off temperature 39 degrees C) was fo...
Topics
- Animals
- Antibodies, Viral
- Cell Line, Transformed
- Chlorocebus aethiops
- Cold Temperature
- Female
- Humans
- Immunization, Passive
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- Neutralization Tests
- Pan troglodytes
- Respiratory Syncytial Viruses