Article
Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus.
Vaccine - 1 Apr 1995
Hsu K H, Crowe J E, Lubeck M D, Davis A R, Hung P P, Chanock R M, Murphy B R
Abstract excerpt
Ts-1, a temperature sensitive (ts) mutant of RSV, was previously derived from RSV A2 virus by mutagenesis with 5-fluorouracil (5-FU). Ts-1 was attenuated for adult volunteers and seropositive children but retained a low level of virulence in seronegative infant vaccinees as indicated by the occurrence of upper respiratory tract disease. Ts-1 NG-1, a more defective derivative of ts-1, was produced by mutagenesis...
Topics
- Animals
- Azacitidine
- Carcinoma, Squamous Cell
- Chlorocebus aethiops
- Female
- Fluorouracil
- Male
- Mice
- Mice, Inbred BALB C
- Mutagenesis
- Pan troglodytes