Article
The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.
Journal of virology - 1 Aug 1997
Juhasz K, Whitehead S S, Bui P T, Biggs J M, Crowe J E, Boulanger C A, Collins P L, Murphy B R
Abstract excerpt
cpts530, a candidate live-virus vaccine, is an attenuated strain of human respiratory syncytial virus (RSV). It was derived by subjecting a cold-passaged (cp) strain of RSV to a single round of chemical mutagenesis. cpts530 is a temperature-sensitive (ts) mutant that is attenuated in mice and chi...
Topics
- HN Protein
- Mutation
- Respiratory Syncytial Virus, Human
- Temperature
- Vaccines, Attenuated
- Vaccines, Synthetic
- Viral Envelope Proteins
- Viral Proteins
- Viral Vaccines