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Article

Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children.

The Journal of infectious diseases - 1 Dec 1997

Karron R A, Wright P F, Crowe J E, Clements-Mann M L, Thompson J, Makhene M, Casey R, Murphy B R

Abstract excerpt

Two live-attenuated, cold-passaged (cp), temperature-sensitive (ts) candidate vaccines, designated cpts530/1009 and cpts248/955, were attenuated, genetically stable, and immunogenic in chimpanzees and were highly attenuated for human adults. In respiratory syncytial virus (RSV)-seropositive children, cpts530/1009 was more restricted in replication than cpts248/955. In seronegative children, 10(4) pfu of...

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PMID: 9395351
DOI: 10.1086/514138

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Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children.PMID 9395351Read ↗

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