Attenuated temperature-sensitive respiratory syncytial virus mutants generated by cold adaptation.

doi:10.1016/0168-1702(94)90106-6

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Article

Attenuated temperature-sensitive respiratory syncytial virus mutants generated by cold adaptation.

Virus research - 1 Sept 1994

Randolph V B, Kandis M, Stemler-Higgins P, Kennelly M S, McMullen Y M, Speelman D J, Weeks-Levy C

Abstract excerpt

Two strains of respiratory syncytial virus (RSV), RSV 2B and RSV 3A (representing subgroup B and A virus respectively) were cold-adapted by passaging in Vero cells for up to 42 weeks at successively lower temperatures down to 20 degrees C. Successful cold adaptation of the virus population was de...

Topics

Adaptation, Physiological
Animals
Antibodies, Viral
Chlorocebus aethiops
Cold Temperature
Humans
Lung
Mutation
Phenotype
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus, Human
Serial Passage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sigmodontinae

Temperature

Turbinates

Vaccines, Attenuated

Vero Cells

Viral Vaccines

Source

Open in PubMed

Identifiers

PMID: 7985411
DOI: 10.1016/0168-1702(94)90106-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7985411-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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