Article
Attenuated temperature-sensitive respiratory syncytial virus mutants generated by cold adaptation.
Virus research - 1 Sept 1994
Randolph V B, Kandis M, Stemler-Higgins P, Kennelly M S, McMullen Y M, Speelman D J, Weeks-Levy C
Abstract excerpt
Two strains of respiratory syncytial virus (RSV), RSV 2B and RSV 3A (representing subgroup B and A virus respectively) were cold-adapted by passaging in Vero cells for up to 42 weeks at successively lower temperatures down to 20 degrees C. Successful cold adaptation of the virus population was dependent on the amount of time the cultures were maintained at the various low temperatures, as well as on the strain of...
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