Article
A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV.
Vaccine - 1 Nov 1993
Crowe J E, Collins P L, London W T, Chanock R M, Murphy B R
Abstract excerpt
Respiratory syncytial virus (RSV) is the most common cause of viral bronchiolitis and pneumonia in children. The present study compares the level of attenuation, genetic stability and efficacy of three conditional-lethal temperature-sensitive (ts) mutants of the RSV A2 wild-type virus, designated ts-1, ts-1-NG1, and ts-4, in seronegative chimpanzees and also compares their efficacy with that of vaccinia virus...
Topics
- Animals
- Female
- HN Protein
- Humans
- Male
- Membrane Glycoproteins
- Mutation
- Pan troglodytes
- Respiratory Syncytial Viruses
- Sensitivity and Specificity
- Temperature
- Vaccines, Attenuated
- Vaccines, Synthetic