A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees.

doi:10.1016/0264-410x(94)90286-0

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Article

A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees.

Vaccine - 1 Jul 1994

Crowe J E, Bui P T, Davis A R, Chanock R M, Murphy B R

Abstract excerpt

A cold-passage (cp), temperature-sensitive (ts) RSV mutant designated RSV cpts-248 (shut-off temperature 38 degrees C), which possesses host-range mutations acquired during 52 passages at low temperature in bovine tissue culture and a ts phenotype introduced by subsequent chemical mutagenesis, was found previously to be attenuated, immunogenic, and protective against wild-type challenge in seronegative...

Topics

Animals
Cattle
Cell Line, Transformed
Chlorocebus aethiops
Cold Temperature
Culture Techniques
Epithelial Cells
Epithelium
Female
Fluorouracil
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred BALB C

Mutagenesis

Pan troglodytes

Phenotype

Respiratory Syncytial Virus Infections

Source

Open in PubMed

Identifiers

PMID: 7975856
DOI: 10.1016/0264-410x(94)90286-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7975856-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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