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Article

Genetic stability determinants of temperature sensitive, live attenuated respiratory syncytial virus vaccine candidates.

Virus research - 1 Jan 2006

Lin Yen-Huei, Deatly Anne M, Chen Wei, Miller Lynn Z, Lerch Robert, Sidhu Mohinderjit S, Udem Stephen A, Randolph Valerie B

Abstract excerpt

An intranasally delivered, live attenuated, temperature sensitive (ts) respiratory syncytial virus vaccine candidate, rA2cp248/404/1,030DeltaSH, exhibits a low level of genetic instability in clinical studies, in contrast to the relatively high stability of two similar candidates, cpts248/404 and rA2cp248/404DeltaSH. The latter strains, containing two ts mutations (248ts and 404ts), are partially growth...

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Identifiers

PMID: 16099066
DOI: 10.1016/j.virusres.2005.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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